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Mutagenesis Advance Access originally published online on February 27, 2008
Mutagenesis 2008 23(4):261-265; doi:10.1093/mutage/gen011
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© The Author 2008. Published by Oxford University Press on behalf of the UK Environmental Mutagen Society. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org.

Protective effects of mate tea (Ilex paraguariensis) on H2O2-induced DNA damage and DNA repair in mice

Daniel D. C. Miranda1, Demétrius P. Arçari1, José Pedrazzoli, Jr1, Patrícia de O. Carvalho2, Suzete M. Cerutti3, Deborah H. M. Bastos4 and Marcelo L. Ribeiro1,*

1Unidade Integrada de Farmacologia e Gastroenterologia, Universidade São Francisco, Av. São Francisco de Assis, 218. Jd. São José, Bragança Paulista, SP, Brazil 2Laboratório Multidisciplinar de Pesquisa, Universidade São Francisco 3Laboratório de Plasticidade Neural e Fitoterápicos, Universidade São Francisco 4Departamento de Nutrição, Escola de Saúde Publica, Universidade de São Paulo, São Paulo, SP, Brazil

Yerba mate (Ilex paraguariensis) is rich in several bioactive compounds that can act as free radical scavengers. Since oxidative DNA damage is involved in various pathological states such as cancer, the aim of this study was to evaluate the antioxidant activity of mate tea as well as the ability to influence DNA repair in male Swiss mice. Forty animals were randomly assigned to four groups. The animals received three different doses of mate tea aqueous extract, 0.5, 1.0 or 2.0 g/kg, for 60 days. After intervention, the liver, kidney and bladder cells were isolated and the DNA damage induced by H2O2 was investigated by the comet assay. The DNA repair process was also investigated for its potential to protect the cells from damage by the same methodology. The data presented here show that mate tea is not genotoxic in liver, kidney and bladder cells. The regular ingestion of mate tea increased the resistance of DNA to H2O2-induced DNA strand breaks and improved the DNA repair after H2O2 challenge in liver cells, irrespective of the dose ingested. These results suggest that mate tea could protect against DNA damage and enhance the DNA repair activity. Protection may be afforded by the antioxidant activity of the mate tea's bioactive compounds.

* To whom correspondence should be addressed. Tel: +55 11 4034 8135; Fax: +55 11 40341825; Email: marcelo.ribeiro{at}saofrancisco.edu.br

Received on October 26, 2007; revised on December 5, 2007; accepted on January 31, 2008.


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